Issue 84, 2022
From the journal:

Chemical Communications

GSH-Triggered NO releasing nanoplatform based on a covalent organic framework for “1 + 1 > 2” synergistic cancer therapy†

Xiuyan Wan,‡a   Teng Zheng,‡a   Dawei Wang,c   Wei Pan, ORCID logo *a   Yanan Gao,*b   Na Li ORCID logo a  and  Bo Tang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan, P. R. China
E-mail: panwei@sdnu.edu.cn, tangb@sdnu.edu.cn

b Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan University, Haikou, P. R. China
E-mail: ygao@hainanu.edu.cn

c Department of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, China

Abstract

A porphyrin containing covalent organic framework (COF) was developed as the glutathione responsive nitric oxide (NO) donor delivery nanoplatform for “1 + 1 > 2” synergistic cancer therapy of NO mediated therapy and photodynamic therapy.

Graphical abstract: GSH-Triggered NO releasing nanoplatform based on a covalent organic framework for “1 + 1 > 2” synergistic cancer therapy

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Article information

DOI
https://doi.org/10.1039/D2CC04393A
Article type
Communication
Submitted
06 Aug 2022
Accepted
26 Sep 2022
First published
27 Sep 2022

Chem. Commun., 2022,58, 11803-11806

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GSH-Triggered NO releasing nanoplatform based on a covalent organic framework for “1 + 1 > 2” synergistic cancer therapy

X. Wan, T. Zheng, D. Wang, W. Pan, Y. Gao, N. Li and B. Tang, Chem. Commun., 2022, 58, 11803 DOI: 10.1039/D2CC04393A

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