Issue 84, 2022
From the journal:

Chemical Communications

Identifying a selective oligopeptide clamp in the gas phase†

Xiaoru Peng,‡a   Mengying Du,‡b   Yong Shen,a   Yu-Xin Ye,a   Xianglei Kong, ORCID logo *bc   Jianqiao Xu ORCID logo *a  and  Gangfeng Ouyang ORCID logo a  

* Corresponding authors

a School of Chemistry, Sun Yat-sen University, Guangzhou 510006, P. R. China
E-mail: xujq@mail.sysu.edu.cn

b State Key Laboratory of Elemento-organic Chemistry, Collage of Chemistry, Nankai University, Tianjin 300071, P. R. China
E-mail: kongxianglei@nankai.edu.cn

c Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China

Abstract

Oligopeptide foldamers are promising as minimalist functional analogues to proteins. Herein, we report a versatile and cost-effective experimental scheme in the gas phase that can facilely identify selective oligopeptides and unambiguously resolve the corresponding folding conformations. Based on this methodology, a stereoselective oligopeptide clamp targeting β2-blockers is successfully identified.

Graphical abstract: Identifying a selective oligopeptide clamp in the gas phase

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Article information

DOI
https://doi.org/10.1039/D2CC04868J
Article type
Communication
Submitted
02 Sep 2022
Accepted
19 Sep 2022
First published
05 Oct 2022

Chem. Commun., 2022,58, 11867-11870

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Identifying a selective oligopeptide clamp in the gas phase

X. Peng, M. Du, Y. Shen, Y. Ye, X. Kong, J. Xu and G. Ouyang, Chem. Commun., 2022, 58, 11867 DOI: 10.1039/D2CC04868J

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