Issue 97, 2022

A general nickel-catalyzed highly regioselective hydroarylation of unactivated alkenes enabled by the picolinamide auxiliary

Abstract

A practical method for regioselective hydroarylation of unactivated γ- or δ-vinyl alkylamines has been reported, enabling facile preparation of highly value-added ε- or ζ-aryl alkylamines. The protocol employs nickel catalysis, shows high functional group tolerance and can be used for modifying bio-related molecules.

Graphical abstract: A general nickel-catalyzed highly regioselective hydroarylation of unactivated alkenes enabled by the picolinamide auxiliary

Supplementary files

Article information

Article type
Communication
Submitted
06 Sep 2022
Accepted
10 Nov 2022
First published
10 Nov 2022

Chem. Commun., 2022,58, 13511-13514

A general nickel-catalyzed highly regioselective hydroarylation of unactivated alkenes enabled by the picolinamide auxiliary

L. Zhang, C. Luo, H. Shi, L. Zhu, Y. Xu, Z. Cao and C. Wang, Chem. Commun., 2022, 58, 13511 DOI: 10.1039/D2CC04932E

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