Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets

Su-Jing Zhao; Haiyu Guo; Zhenkun Wu; Jian-Hui Jiang

doi:10.1039/D2CC05628C

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Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets†

Su-Jing Zhao,^a Haiyu Guo,^a Zhenkun Wu

*^a and Jian-Hui Jiang

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* Corresponding authors

^a State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
E-mail: tomwu@hnu.edu.cn

Abstract

Tetrazine-mediated bioorthogonal reactions were rationally coupled with DNA cascade circuits to enable proximal decaging, which allowed the construction of a fluorogenic aptasensor for the accurate and amplified sensing of non-nucleic acid targets in live cells.

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Article information

DOI: https://doi.org/10.1039/D2CC05628C
Article type: Communication
Submitted: 16 Oct 2022
Accepted: 07 Nov 2022
First published: 08 Nov 2022

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Chem. Commun., 2022,58, 13393-13396

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Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets

S. Zhao, H. Guo, Z. Wu and J. Jiang, Chem. Commun., 2022, 58, 13393 DOI: 10.1039/D2CC05628C

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Chemical Communications

Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets†

Abstract

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Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets

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