Issue 7, 2022

A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

Abstract

A new dinuclear cyclic gold(I) complex [Au2(DCyPA)2](PF6)2, 1, based on bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) has been synthesized and characterized by elemental analysis, IR and NMR spectroscopy, and X-ray crystallography. In the dinuclear complex cation [Au2(DCyPA)2]2+, the two gold(I) ions are bridged by the ligand bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) giving rise to a 16-membered ring centrosymmetric metallacycle. The cytotoxicity of the complex was evaluated against the triple-negative human breast cancer cells MDA-MB-231. In order to understand the mechanism of the cytotoxic behavior, a variety of assays, including Annexin V-FITC/Propidium iodide double staining, ROS production, and mitochondrial membrane potential and migration assays were carried out. The results indicated that complex 1 induced cytotoxicity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells.

Graphical abstract: A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

Supplementary files

Article information

Article type
Paper
Submitted
21 Oct 2021
Accepted
30 Dec 2021
First published
30 Dec 2021

Dalton Trans., 2022,51, 2760-2769

A novel cyclic dinuclear gold(I) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

A. K. Abogosh, M. K. Alghanem, S. Ahmad, A. Al-Asmari, H. M. As Sobeai, A. A. A. Sulaiman, M. Fettouhi, S. A. Popoola, A. Alhoshani and A. A. Isab, Dalton Trans., 2022, 51, 2760 DOI: 10.1039/D1DT03546K

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