Three novel metal–organic frameworks with different coordination modes for trace detection of anthrax biomarkers

Abstract

Dipicolinic acid (DPA) is an anthrax biomarker. Its serious consequences make its detection a great need. In this paper, three novel metal–organic frameworks (MOFs) with different coordination modes were synthesized by a simple solvothermal method, which can be used as highly efficient fluorescence sensors for the highly selective and sensitive trace detection of DPA. MOFs 1–3 showed rapid responses to DPA (<30 s), and the limits of detection (LODs) were calculated to be 1.01 × 10⁻⁶ M⁻¹ (MOF 1), 1.17 × 10⁻⁶ M⁻¹ (MOF 2) and 2.07 × 10⁻⁶ M⁻¹ (MOF 3). DPA detection based on MOFs 1–3 in fetal bovine serum is highly reliable based on the high recovery rates (90% to 115%). Hence, the three MOF-based sensors can be used in the real-time detection of DPA.