Issue 14, 2022

A platinum-based fluorescent “turn on” sensor to decipher the reduction of platinum(iv) prodrugs

Abstract

We report a strategy to use a fluorescence “turn on” sensor to quantify the reduction of platinum(IV) prodrugs in a real-time mode by simply and conveniently monitoring the fluorescence intensity. Proteins with high molecular weights, especially those between 10 and 100 kDa, contribute more to the reduction of the platinum(IV) complex in cell extracts.

Graphical abstract: A platinum-based fluorescent “turn on” sensor to decipher the reduction of platinum(iv) prodrugs

Supplementary files

Article information

Article type
Communication
Submitted
14 Jan 2022
Accepted
24 Feb 2022
First published
25 Feb 2022

Dalton Trans., 2022,51, 5394-5398

A platinum-based fluorescent “turn on” sensor to decipher the reduction of platinum(IV) prodrugs

H. Yao and G. Zhu, Dalton Trans., 2022, 51, 5394 DOI: 10.1039/D2DT00124A

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