Issue 29, 2022
From the journal:

Dalton Transactions

Photocatalytic glucose-appended bio-compatible Ir(iii) anticancer complexes†

Zilin Zhu,a   Li Wei,a   Yidan Lai,b   Oliver W. L. Carter, ORCID logo c   Samya Banerjee, ORCID logo d   Peter J. Sadler ORCID logo *c  and  Huaiyi Huang ORCID logo *a  

* Corresponding authors

a School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, P. R. China
E-mail: huanghy87@mail.sysu.edu.cn

b College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, P. R. China

c Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
E-mail: P.J.Sadler@warwick.ac.uk

d Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, India

Abstract

Rationally-designed glucose-appended Ir(III) photo-catalysts ([Ir(N,C)2(N,N-Glc)]+, Ir1–Ir3) show visible light-induced catalytic NAD(P)H oxidation in aqueous solution. The highly in vivo biocompatible complex, Ir3, shows lysosome and mitochondria targeting necro-apoptotic photo-cytotoxicity against various cancer cell lines and multicellular spheroids, while remaining non-toxic in the dark.

Graphical abstract: Photocatalytic glucose-appended bio-compatible Ir(iii) anticancer complexes

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Article information

DOI
https://doi.org/10.1039/D2DT01134D
Article type
Communication
Submitted
12 Apr 2022
Accepted
18 Jun 2022
First published
20 Jun 2022

Dalton Trans., 2022,51, 10875-10879

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Photocatalytic glucose-appended bio-compatible Ir(III) anticancer complexes

Z. Zhu, L. Wei, Y. Lai, O. W. L. Carter, S. Banerjee, P. J. Sadler and H. Huang, Dalton Trans., 2022, 51, 10875 DOI: 10.1039/D2DT01134D

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