Curcumin-based ionic Pt(II) complexes: antioxidant and antimicrobial activity

Rossella Caligiuri; Giuseppe Di Maio; Nicolas Godbert; Francesca Scarpelli; Angela Candreva; Isabella Rimoldi; Giorgio Facchetti; Maria Giovanna Lupo; Emilia Sicilia; Gloria Mazzone; Fortuna Ponte; Isabella Romeo; Massimo La Deda; Alessandra Crispini; Renata De Rose; Iolinda Aiello

doi:10.1039/D2DT01653B

Curcumin-based ionic Pt(ii) complexes: antioxidant and antimicrobial activity†

Rossella Caligiuri,^a Giuseppe Di Maio,^a Nicolas Godbert,

^a Francesca Scarpelli,

^a Angela Candreva,

^ab Isabella Rimoldi,

^c Giorgio Facchetti,

^c Maria Giovanna Lupo,^d Emilia Sicilia,

^e Gloria Mazzone,

^e Fortuna Ponte,^e Isabella Romeo,^fg Massimo La Deda,

^ab Alessandra Crispini,^a Renata De Rose^h and Iolinda Aiello

*^ab

Author affiliations

* Corresponding authors

^a MAT-INLAB, LASCAMM CR-INSTM, Unità INSTM della Calabria, Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, 87036 Arcavacata di Rende, CS, Italy
E-mail: iolinda.aiello@unical.it

^b CNR NANOTEC-Istituto di Nanotecnologia UOS Cosenza, 87036 Arcavacata di Rende, CS, Italy

^c Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, 20133 Milan, Italy

^d Dipartimento di Medicina, Università degli Studi di Padova, 35128 Padova, Italy

^e Dipartimento di Chimica e Tecnologie Chimiche, 87036 Arcavacata di Rende, CS, Italy

^f Dipartimento di Scienze della Salute, Università degli Studi “Magna Græcia” di Catanzaro, Campus “S. Venuta”, Viale Europa, 88100 Catanzaro, Italy

^g Net4Science Academic Spin-Off, Università degli Studi “Magna Græcia” di Catanzaro, Campus “S. Venuta”, Viale Europa, 88100 Catanzaro, Italy

^h LAB CF-INABEC, Dipartimento di Chimica e Tecnologie Chimiche, 87036 Arcavacata di Rende, CS, Italy

Abstract

A series of novel cationic curcumin-based Pt(II) complexes with neutral (N^N) ligands and triflate anions as counterions, [(N^N)Pt(curc)]CF₃SO₃, 1–4, were synthesised and fully characterised. The antioxidant radical scavenging activity of complexes 1–4 was measured spectrophotometrically using DPPH as the internal probe. Computational strategies have been exploited to ascertain the mechanism of antioxidant action of curcumin (H(curc)) and its Pt(II) complexes. Finally, compounds 1–4 were tested in vitro for their growth inhibitory activity against two bacteria (Staphylococcus aureus and Escherichia coli) by the disk diffusion technique at different Pt(II) complex solution concentrations. The effect of the complexation of H(curc) was investigated.

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Curcumin-based ionic Pt(ii) complexes: antioxidant and antimicrobial activity†

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Curcumin-based ionic Pt(II) complexes: antioxidant and antimicrobial activity

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