Sustainable and fast synthesis of functionalized quinoxalines promoted by natural deep eutectic solvents (NADESs)

Abstract

Functionalized quinoxalines, embedding acid sensitive protecting groups, can be prepared with a fast (5 min) and high yielding (>90%) protocol using a choline chloride/water NADES at room temperature without any additional activation. The products obtained after solvent extraction do not require any further purification. The NADES used can be recycled up to six times maintaining the same efficiency level.