Issue 12, 2022

Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction

Abstract

We developed an environmentally friendly mechanochemical protocol to induce an effective Fischer indolisation to synthesize indoles and indolines taking advantage of oxalic acid and dimethylurea. The solvent-free procedure shows versatility and wide scope; it applies to a broad range of arylhydrazines and carbonyl compounds, leading to variously decorated indoles and indolenines. Upon suitable modification, the methodology can also allow preparing compounds of pharmaceutical interest.

Graphical abstract: Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction

Supplementary files

Article information

Article type
Paper
Submitted
22 Feb 2022
Accepted
06 May 2022
First published
11 May 2022
This article is Open Access
Creative Commons BY license

Green Chem., 2022,24, 4859-4869

Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction

A. Porcheddu, R. Mocci, M. Brindisi, F. Cuccu, C. Fattuoni, F. Delogu, E. Colacino and M. V. D'Auria, Green Chem., 2022, 24, 4859 DOI: 10.1039/D2GC00724J

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