Highly efficient and fast synthesis of di-iodinated succinimide derivatives from 1,6-enyne and I2 under air at room temperature

Abstract

Without using any additives, a green and efficient procedure for the preparation of valuable di-iodinated succinimide derivatives has been achieved through the iodine radical-initiated cascade cyclization of 1,6-enynes. This protocol could be conducted in MeCN in open air at room temperature with good to excellent yields. Notably, this method is highly atom- and time-economical, safe to operate, easy to scale up, and has excellent functional group compatibility. Moreover, this is the first example of di-iodinolysis cyclization using iodine radical cascade reaction.