Issue 20, 2022

Enantiocomplementary synthesis of vicinal fluoro alcohols through photo-bio cascade reactions

Abstract

The combination of the catalytic power of photocatalysis and biocatalysis has greatly boosted the development of novel synthetic strategies due to its functional diversity and stereoselective specificity. Herein, we describe a one-pot cascade process that combined photo-oxidative fluoridation and bio-reduction to access enantiocomplementary vicinal fluoro alcohols with up to 87% isolated yield and 99% ee.

Graphical abstract: Enantiocomplementary synthesis of vicinal fluoro alcohols through photo-bio cascade reactions

Supplementary files

Article information

Article type
Communication
Submitted
20 Jul 2022
Accepted
16 Sep 2022
First published
19 Sep 2022

Green Chem., 2022,24, 7889-7893

Enantiocomplementary synthesis of vicinal fluoro alcohols through photo-bio cascade reactions

Y. Zhang, H. Liu, Q. Shi, X. Chen and X. Xie, Green Chem., 2022, 24, 7889 DOI: 10.1039/D2GC02701A

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