The non-fluorescent 9-nitrobenzo[b]quinolizinium is readily reduced by nitroreductase to a fluorescent reaction product. The resulting light-up effect enables the selective detection of nitroreductase activity in vitro and in Escherichia coli bacterial cultures.
![Graphical abstract: 9-Nitrobenzo[b]quinolizinium as a fluorogenic probe for the detection of nitroreductase in vitro and in Escherichia coli](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D1NJ05230F&imageInfo.ImageIdentifier.Year=2022)
P. J. Wickhorst, H. Ihmels, M. M. Lammert-Baumgartner, M. Müller and H. Schönherr, New J. Chem., 2022, 46, 39 DOI: 10.1039/D1NJ05230F
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