One-pot synthesis of 4-substituted 2-fluoroalkyloxazoles from NH-1,2,3-triazoles and fluoroalkylated acid anhydrides

Abstract

An efficient one-pot method for the synthesis of 2-fluoroalkyloxazoles from 4-substituted NH-1,2,3-triazoles, fluorinated anhydrides and triethylamine was developed. Structurally diverse fluoroalkylated oxazoles (R_F = CF₃, C₂F₅, CF₂Cl, CF₂H) were prepared in high yields from readily available starting reagents in mild conditions. An alternative direct method for fluoroalkylated oxazole synthesis from electron-rich NH-triazoles using acetonitrile as the solvent was described.