Cis and trans platinum(II) N-heterocyclic carbene isomers: synthesis, characterization and biological activity

Carolina Rivera; Héctor A. Bacilio-Beltrán; Ana M. Puebla-Pérez; Irma I. Rangel-Salas; José G. Alvarado-Rodríguez; Roberto Flores-Moreno; Gilberto Velázquez-Juárez; A. Aarón Peregrina-Lucano; Elvia Becerra-Martínez; Jaime Valdez-Ruvalcaba; José E. Rubio; Sara A. Cortés-Llamas

doi:10.1039/D2NJ02508F

Cis and trans platinum(ii) N-heterocyclic carbene isomers: synthesis, characterization and biological activity†

Carolina Rivera,^a Héctor A. Bacilio-Beltrán,

^a Ana M. Puebla-Pérez,^b Irma I. Rangel-Salas,

^a José G. Alvarado-Rodríguez,

^c Roberto Flores-Moreno,^a Gilberto Velázquez-Juárez,^a A. Aarón Peregrina-Lucano,^b Elvia Becerra-Martínez,^d Jaime Valdez-Ruvalcaba,^a José E. Rubio

^e and Sara A. Cortés-Llamas

*^a

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* Corresponding authors

^a Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Marcelino García Barragán #1421, esq. Olímpica, Guadalajara, Jalisco, Mexico
E-mail: sara.cortes@academicos.udg.mx

^b Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Marcelino García Barragán #1421, esq. Olímpica, Guadalajara, Jalisco, Mexico

^c Universidad Autónoma del Estado de Hidalgo. Unidad Universitaria, km 4.5 Carretera Pachuca-Tulancingo, C.P. 42184, Mineral de la Reforma, Hidalgo, Mexico

^d Centro de Nanociencias y Micro y Nanotecnologías, Instituto Politécnico Nacional. Unidad Profesional “Adolfo López Mateos”, Luis Enrique Erro S/N, Zacatenco, DF, Mexico

^e Department of Electronics, ETSIT, University of Valladolid, Paseo Belen 15, Valladolid, Spain

Abstract

The synthesis of cis and trans geometrical isomers of platinum(II) complexes with a symmetric N-heterocyclic carbene ligand (^MeNHC) is reported. These complexes were obtained from 1,3-dimethylimidazolium-2-carboxylate, a masked NHC precursor. Their cytotoxicity, oxidative nature, and antibacterial behavior were investigated. The highest cytotoxic effect (IC₅₀ = 1.21 μM) was observed with the cis-[Pt(^MeNHC)₂Cl₂] complex in the cervix cancerous cell line HeLa.

New Journal of Chemistry

Cis and trans platinum(ii) N-heterocyclic carbene isomers: synthesis, characterization and biological activity†

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