BF3·OEt2 catalyzed S–H insertion reactions of α-diazo imidamides and enolizable thioamides under metal-free conditions

Abstract

BF₃·OEt₂ catalyzed S–H insertion reactions of α-diazo imidamides and substituted thioureas/thiosemicarbazones/cyclic thioamides were demonstrated to furnish the corresponding S–H insertion products. This method features wide substrate applicability and resistance to moisture and air, affording moderate to excellent yield. The products were characterized by NMR, IR and mass spectral analyses, and a representative product was confirmed by single crystal X-ray diffraction analysis.