Radial ZnO nanorods decorating Co3O4 nanoparticles for highly selective and sensitive detection of the 3-hydroxy-2-butanone biomarker

Abstract

Indirect monitoring of Listeria monocytogenes (LM) via a gas sensor that can detect the bacterial metabolite 3-hydroxy-2-butanone (3H-2B) is a newly emerged strategy. However, such sensors are required simultaneously endow with outstanding selectivity, high sensitivity, and ppb-level detection limit, which remains technologically challenging. Herein, we have developed highly selective and sensitive 3H-2B sensors that consist of zinc oxide nanorods decorated with cobaltosic oxide nanoparticles (ZnO NRs/Co₃O₄ NPs), which have been synthesized by combined optimized hydrothermal and annealing process. Specifically, the ZnO NRs/Co₃O₄ NPs exhibit ultrahigh sensitivity to 5 ppm 3H-2B (R_a/R_g = 550 at 260 °C). The sensor prototypes enable detection as low as 10 ppb 3H-2B, show excellent long-term stability, and present remarkable selectivity through interfering selectivity survey and principal component analysis (PCA). Such outstanding sensing performance is attributed to the modulated electron depletion layer by n–p heterojunctions and abundant gas diffusion pathways via the radial architecture, which was verified via electrochemical impedance spectroscopy test, Mott–Schottky measurement, and ultraviolet-visible absorption analysis. Our highly selective and sensitive ZnO NRs/Co₃O₄ NPs have the potential in the real-time detection of 3H-2B biomarker.