Transition metal-catalyzed regioselective functionalization of carbazoles and indolines with maleimides

Abstract

The directing group-assisted regioselective C–H activation of carbazoles and indolines is achieved via transition metal-catalyzed reactions. This C–H functionalization protocol provides a rapid approach to install diversely functionalized succinimide groups at the C-1 position of the carbazole moiety. In addition, this protocol demonstrates the intrinsic reactivity of indolines in providing C-2 succinimide-substituted indoles via cascade direct oxidation and C–H functionalization. This protocol also provides C-7 succinimide-substituted indolines under mild reaction conditions. The features of this reaction include a wide substrate scope and excellent regioselectivity for the installation of the succinimide moiety on biologically interesting molecules.