Issue 15, 2022

A one-pot synthesis of PEGylated plasmonic WO3−x@Eugenol nanoflowers with NIR-controllable antioxidant activities for synergetically combating bacterial biofilm infection

Abstract

Serious wound infection by the colonization and development of drug-resistant bacteria has attracted widespread attention of the society with the urge for searching advanced antibacterial methods. The NIR-triggered antimicrobial photothermal therapy (PTT) using nanomaterials as energy donors has the advantage of a wide antibacterial spectrum, but it is still restricted by its low efficacy. Herein, we propose a PTT-driven bioactive molecule controllable release system (PEG-WO3−x@EL NFs), which is developed with tungsten trioxide nanoflowers as a carrier. Benefiting from the photothermal effect of PEG-WO3−x NFs and the inherent bactericidal properties of EL (eugenol), the nanoplatform achieves an extremely strong bactericidal ability against Salmonella and methicillin-resistant Staphylococcus aureus. Notably, the nanoplatform presents outstanding capacity to prevent biofilm formation. More importantly, the nanoplatform displays significant antioxidant capacity to realize the rapid recovery of infected wounds. As a consequence, our study has the potential to provide an urgent breakthrough for wound biofilm therapy.

Graphical abstract: A one-pot synthesis of PEGylated plasmonic WO3−x@Eugenol nanoflowers with NIR-controllable antioxidant activities for synergetically combating bacterial biofilm infection

Supplementary files

Article information

Article type
Research Article
Submitted
16 Mar 2022
Accepted
01 Jun 2022
First published
21 Jun 2022

Inorg. Chem. Front., 2022,9, 3808-3819

A one-pot synthesis of PEGylated plasmonic WO3−x@Eugenol nanoflowers with NIR-controllable antioxidant activities for synergetically combating bacterial biofilm infection

X. Xie, M. Zhang, Y. Lei, Y. Li, J. Sun, N. Sattorov, K. B. Makhmudov, M. Zhu and J. Wang, Inorg. Chem. Front., 2022, 9, 3808 DOI: 10.1039/D2QI00571A

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