Issue 4, 2022

Access to enantioenriched molecules with diverse fluorinated tetrasubstituted stereocenters using hydroxy as a kinetic resolution auxiliary group

Abstract

Developing a general method affording optically pure fully substituted carbon molecules bearing various fluorinated groups is highly important but very challenging. Here we show that using secondary OH as a kinetic resolution auxiliary group, a series of previously unavailable fluorinated fully substituted carbon molecules can be obtained with excellent enantioselectivities, thus providing an alternative complementary method that provides solutions to the limitations confronted by the known methods.

Graphical abstract: Access to enantioenriched molecules with diverse fluorinated tetrasubstituted stereocenters using hydroxy as a kinetic resolution auxiliary group

Supplementary files

Article information

Article type
Research Article
Submitted
05 Oct 2021
Accepted
05 Jan 2022
First published
06 Jan 2022

Org. Chem. Front., 2022,9, 1040-1047

Access to enantioenriched molecules with diverse fluorinated tetrasubstituted stereocenters using hydroxy as a kinetic resolution auxiliary group

S. T. Zehra, S. Lan, H. Zhang, J. Liu, S. Yang and X. Fang, Org. Chem. Front., 2022, 9, 1040 DOI: 10.1039/D1QO01493E

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