Issue 6, 2022

Asymmetric synthesis of tricyclic 6,5,5-fused polycycles by the desymmetric Pauson–Khand reaction

Abstract

A new rhodium(I)–BINAP-catalyzed enantioselective desymmetric Pauson–Khand (PK) reaction of prochiral 1,6-enynes with CO has been developed. Diverse tricyclic 6,5,5-fused bowl type polycycles with three continuous chiral centers were synthesized in one step with a single diastereomer and extremely high enantioselectivities.

Graphical abstract: Asymmetric synthesis of tricyclic 6,5,5-fused polycycles by the desymmetric Pauson–Khand reaction

Supplementary files

Article information

Article type
Research Article
Submitted
18 Dec 2021
Accepted
30 Jan 2022
First published
05 Feb 2022

Org. Chem. Front., 2022,9, 1680-1685

Asymmetric synthesis of tricyclic 6,5,5-fused polycycles by the desymmetric Pauson–Khand reaction

Q. Teng, D. Chen, C. Tung and Z. Xu, Org. Chem. Front., 2022, 9, 1680 DOI: 10.1039/D1QO01878G

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