Issue 5, 2022

Molecular editing in natural product synthesis

Abstract

Many natural products have remarkable biological functions due to their fascinating molecular architectures. Despite many advances in synthetic method development, the efficient synthesis of highly functionalized and structurally intricate natural products to meet the demand for biological investigations remains a daunting challenge. Molecular editing encompassing insertion, deletion, or exchange of atoms of highly functionalized compounds has emerged as a hotspot in new method development and has been applied in complex natural product synthesis. In this highlight, the latest developments in molecular editing in natural product synthesis are discussed.

Graphical abstract: Molecular editing in natural product synthesis

Article information

Article type
Highlight
Submitted
12 Jan 2022
Accepted
07 Feb 2022
First published
10 Feb 2022

Org. Chem. Front., 2022,9, 1451-1457

Molecular editing in natural product synthesis

C. Hui, Z. Wang, S. Wang and C. Xu, Org. Chem. Front., 2022, 9, 1451 DOI: 10.1039/D2QO00043A

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