Issue 11, 2022

Synthesis of α-trifluoromethyl sulfides through fluorosulfuration of gem-difluoroalkenes

Abstract

A new fluoro-sulfuration of gem-difluoroalkenes is demonstrated that occurs through a nucleophilic fluorination and subsequent interrupted electrophilic sulfuration cascade. By intercepting the in situ generated α-trifluoromethyl carbanion intermediates with electrophilic benzenesulfonothioates, diverse α-trifluoromethyl sulfides were synthesized in high yields under mild conditions.

Graphical abstract: Synthesis of α-trifluoromethyl sulfides through fluorosulfuration of gem-difluoroalkenes

Supplementary files

Article information

Article type
Research Article
Submitted
09 Mar 2022
Accepted
09 Apr 2022
First published
14 Apr 2022

Org. Chem. Front., 2022,9, 2926-2931

Synthesis of α-trifluoromethyl sulfides through fluorosulfuration of gem-difluoroalkenes

T. Song, C. Tung and Z. Xu, Org. Chem. Front., 2022, 9, 2926 DOI: 10.1039/D2QO00391K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements