Efficient radical C(sp3)–H α-oxyamination of carbonyls adjacent to the carbon chalcogen bond

Abstract

An efficient radical C(sp³)–H α-oxyamination of carbonyls adjacent to different chalcogens (e.g., S, O, and Se) at the α-position is demonstrated. This radical oxyamination process proceeds under solvent-free conditions without the use of a transition metal catalyst, chemical oxidant or photocatalyst and exhibits a wide substrate scope of chalcogen-containing carbonyls with high functional group tolerance.