Issue 12, 2022

Stereoselective synthesis of 1,3,5-trienes from alkynones and allyl carbonyl compounds through C–C σ-bond cleavage under transition-metal-free conditions

Abstract

An atom-economical transition-metal-free protocol for the stereoselective synthesis of conjugated trienes has been developed. These transformations were realized through base promoted C–C σ-bond cleavage reactions of allyl carbonyl compounds. This methodology efficiently constructs a broad range of conjugated trienes with the advantages of mild reaction conditions, low cost and operational simplicity.

Graphical abstract: Stereoselective synthesis of 1,3,5-trienes from alkynones and allyl carbonyl compounds through C–C σ-bond cleavage under transition-metal-free conditions

Supplementary files

Article information

Article type
Research Article
Submitted
16 Apr 2022
Accepted
03 May 2022
First published
05 May 2022

Org. Chem. Front., 2022,9, 3354-3359

Stereoselective synthesis of 1,3,5-trienes from alkynones and allyl carbonyl compounds through C–C σ-bond cleavage under transition-metal-free conditions

L. Cheng, M. Wang, Y. Yang, Z. Wang, Y. Zhu, L. Kong and Y. Li, Org. Chem. Front., 2022, 9, 3354 DOI: 10.1039/D2QO00617K

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