Three-component synthesis of β-aminoxy amides

Abstract

A multicomponent reaction for the synthesis of β-aminoxy amides is described. In this reaction, N-hydroxamic acids, ynamides and aldehydes could assemble efficiently to deliver structurally diverse β-aminoxy amides under the promotion of BF₃–Et₂O. This protocol features readily available starting materials, high atom economy, mild reaction conditions and facile scalability. Control reactions and a crossover experiment provide insights into the process for elucidating a plausible mechanism.