Palladium-catalyzed cross-coupling of 2-iodobiphenyls with ortho-chloroacetophenones through dual C–H arylation for the construction of tribenzo[a,c,f]cyclooctanones

Abstract

The palladium-catalyzed cross-coupling reaction of 2-iodobiphenyls with ortho-chloroacetophenones has been developed. The reaction involves C–H activation of 2-iodobiphenyls and yields eight-membered carbocycles by forming two C–C bonds. The protocol provides a straightforward method for the construction of tribenzo[a,c,f]cyclooctanones with simple substrates and allows easy access to its various derivatives.