Issue 15, 2022

Total synthesis of thioamycolamide A using diastereoselective sulfa-Michael addition as the key step

Abstract

The stereocontrolled total synthesis of the antitumor natural product thioamycolamide A has been accomplished in 14 longest linear steps and an overall yield of 19.1%. The central feature of our convergent route to this family of novel macrocyclic natural products is the preparation of the β-alkylthio amide subunit through an auxiliary-controlled, diastereoselective sulfa-Michael addition.

Graphical abstract: Total synthesis of thioamycolamide A using diastereoselective sulfa-Michael addition as the key step

Supplementary files

Article information

Article type
Research Article
Submitted
09 May 2022
Accepted
12 Jun 2022
First published
14 Jun 2022

Org. Chem. Front., 2022,9, 3998-4002

Total synthesis of thioamycolamide A using diastereoselective sulfa-Michael addition as the key step

Y. Xiao, Y. Jiang, C. Xu, P. Nakliang, S. Yoon, S. Choi, Y. Guo and T. Ye, Org. Chem. Front., 2022, 9, 3998 DOI: 10.1039/D2QO00747A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements