Issue 17, 2022

Access to cyclopentenones via copper-catalyzed 5-endo trifluoromethylcarbocyclization of ynones

Abstract

A Cu-catalyzed 5-endo-selective trifluoromethylcarbocyclization of ynones is developed for the concise synthesis of trifluoromethylated cyclopentenones. The pivotal roles of carbonyl groups are well illustrated by experiments and density functional theory calculations.

Graphical abstract: Access to cyclopentenones via copper-catalyzed 5-endo trifluoromethylcarbocyclization of ynones

Supplementary files

Article information

Article type
Research Article
Submitted
24 May 2022
Accepted
16 Jul 2022
First published
19 Jul 2022

Org. Chem. Front., 2022,9, 4670-4675

Access to cyclopentenones via copper-catalyzed 5-endo trifluoromethylcarbocyclization of ynones

S. Le, Y. Bai, J. Qiu, Z. Zhang, H. Zheng and G. Zhu, Org. Chem. Front., 2022, 9, 4670 DOI: 10.1039/D2QO00843B

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