Asymmetric cross Rauhut–Currier reactions of vinyl ketones with carbonyl para-quinone methides via phosphine catalysis

Abstract

Novel cross Rauhut–Currier reactions involving chiral phosphine catalysis between vinyl ketones and terminal-carbonyl-substituted para-quinone methides have been presented. This reaction approach showed broad substrate scope compatibility and moderate-to-excellent enantioselectivity control. The multifunctional products could be easily transformed to important and useful skeletons. Moreover, natural-product and drug derivatives were well tolerated in this methodology, exhibiting the promising applications of this reaction approach.