Issue 20, 2022

Lewis acid-promoted cyclizations of o-alkyloxyphenyl-substituted ynamides to construct 2-amidobenzofurans

Abstract

Lewis acid-promoted cyclizations of o-alkyloxyphenyl-substituted ynamides are described for the general construction of medicinally relevant 2-amidobenzofurans. A diverse array of 3-acyl-2-amidobenzofurans could be effectively constructed via a SnCl4-promoted intermolecular reaction. And the 3-unsubstituted 2-amidobenzofurans could be obtained efficiently through a ZnCl2-promoted intramolecular reaction.

Graphical abstract: Lewis acid-promoted cyclizations of o-alkyloxyphenyl-substituted ynamides to construct 2-amidobenzofurans

Supplementary files

Article information

Article type
Research Article
Submitted
03 Aug 2022
Accepted
30 Aug 2022
First published
01 Sep 2022

Org. Chem. Front., 2022,9, 5637-5642

Lewis acid-promoted cyclizations of o-alkyloxyphenyl-substituted ynamides to construct 2-amidobenzofurans

H. Xu, Y. Liu, L. Ding, X. Wang and J. Chang, Org. Chem. Front., 2022, 9, 5637 DOI: 10.1039/D2QO01246D

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