Issue 21, 2022
From the journal:

Organic Chemistry Frontiers

Ligand-controlled regiodivergent direct arylation of indoles via oxidative boron Heck reaction†

Yo-Sep Yang,‡a   Sangmin Lee,‡a   Seung Hwan Son,a   Hyung-Seok Yoo,a   Yoon Hu Jang,a   Jeong-Won Shin,a   Hyuck-Jae Won,a   Jaehoon Sim ORCID logo *b  and  Nam-Jung Kim ORCID logo *a  

* Corresponding authors

a College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea
E-mail: kimnj@khu.ac.kr

b College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea
E-mail: jsim@cnu.ac.kr

Abstract

Ligand-controlled direct arylation of indoles via Pd(II) catalyzed oxidative boron Heck reaction under aerobic conditions is reported. This methodology provides a regiodivergent route for C2 or C3 aryl indoles in a protection free and acid/base free manner.

Graphical abstract: Ligand-controlled regiodivergent direct arylation of indoles via oxidative boron Heck reaction

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Article information

DOI
https://doi.org/10.1039/D2QO01326F
Article type
Research Article
Submitted
22 Aug 2022
Accepted
15 Sep 2022
First published
16 Sep 2022

Org. Chem. Front., 2022,9, 5906-5911

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Ligand-controlled regiodivergent direct arylation of indoles via oxidative boron Heck reaction

Y. Yang, S. Lee, S. H. Son, H. Yoo, Y. H. Jang, J. Shin, H. Won, J. Sim and N. Kim, Org. Chem. Front., 2022, 9, 5906 DOI: 10.1039/D2QO01326F

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