Issue 11, 2022

Three-component assembly of stabilized fluorescent isoindoles

Abstract

The tandem addition of an amine and a thiol to an aromatic dialdehyde engages a selective three-component assembly of a fluorescent isoindole. While an attractive approach for diversity-based fluorophore discovery, isoindoles are typically unstable and present considerable challenges for their practical utility. We found that introduction of electron-withdrawing substituents into the dialdehyde component affords stable isoindole products in one step with acceptable yields and high purity.

Graphical abstract: Three-component assembly of stabilized fluorescent isoindoles

Supplementary files

Article information

Article type
Paper
Submitted
24 Jan 2022
Accepted
23 Feb 2022
First published
02 Mar 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 6947-6950

Three-component assembly of stabilized fluorescent isoindoles

V. A. Maslivetc, J. J. La Clair and A. Kornienko, RSC Adv., 2022, 12, 6947 DOI: 10.1039/D2RA00505K

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