Issue 34, 2022
From the journal:

RSC Advances

Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy†

Hefei Ruan, ORCID logo ‡*ab   Xuejie Zhang,‡c   Jinghe Yuana  and  Xiaohong Fang ORCID logo *a  

* Corresponding authors

a Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: ruanhefei@iccas.ac.cn, xfang@iccas.ac.cn

b Tsinghua-Peking University Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China

c Collaborative Innovation Center of Assessment Toward Basic Education Quality, Beijing Normal University, Beijing, China

Abstract

C60-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples.

Graphical abstract: Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy

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Article information

DOI
https://doi.org/10.1039/D2RA02403A
Article type
Paper
Submitted
14 Apr 2022
Accepted
31 Jul 2022
First published
10 Aug 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 22197-22201

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Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy

H. Ruan, X. Zhang, J. Yuan and X. Fang, RSC Adv., 2022, 12, 22197 DOI: 10.1039/D2RA02403A

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