Issue 49, 2022

Assessment of a host–guest interaction in a bilayer membrane model

Abstract

Supramolecular interactions are well recognized and many of them have been extensively studied in chemistry. The formation of supramolecular complexes that rely on weak force interactions are less well studied in bilayer membranes. Herein, a supported bilayer membrane is used to probe the penetration of a complex between tetracycline and a macrocyclic polyether. In a number of bacterial systems, the presence of the macrocycle has been found to significantly enhance the potency of the antimicrobial in vitro. The crown·tetracycline complex has been characterized in solution, neutron reflectometry has probed complex penetration, and the phenomena have been modeled by computational methods.

Graphical abstract: Assessment of a host–guest interaction in a bilayer membrane model

Supplementary files

Article information

Article type
Paper
Submitted
22 Jun 2022
Accepted
20 Oct 2022
First published
10 Nov 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 32046-32055

Assessment of a host–guest interaction in a bilayer membrane model

H. Kumari, S. Negin, A. Eisenhart, M. B. Patel, T. L. Beck, F. Heinrich, H. J. Spikes and G. W. Gokel, RSC Adv., 2022, 12, 32046 DOI: 10.1039/D2RA03851J

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