Issue 46, 2022, Issue in Progress
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RSC Advances

Concise two-step chemical synthesis of molnupiravir†

Vinícius R. D. Pereira,a   Marco A. M. Bezerra,b   Mauro R. B. P. Gomez,b   Guilherme M. Martins, ORCID logo c   Adilson D. da Silva,a   Kleber T. de Oliveira, ORCID logo c   Rodrigo O. M. A. de Souza ORCID logo *b  and  Giovanni W. Amarante*a  

* Corresponding authors

a Department of Chemistry, Federal University of Juiz de Fora, Campus Martelos, Juiz de Fora, Minas Gerais 36036-900, Brazil
E-mail: giovanni.amarante@ufjf.edu.br

b Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro 22041-909, Brazil

c Department of Chemistry, Federal University of São Carlos, Campus São Carlos, São Carlos, São Paulo 13565-905, Brazil

Abstract

A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%.

Graphical abstract: Concise two-step chemical synthesis of molnupiravir

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Article information

DOI
https://doi.org/10.1039/D2RA05064A
Article type
Paper
Submitted
12 Aug 2022
Accepted
14 Oct 2022
First published
21 Oct 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 30120-30124

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Concise two-step chemical synthesis of molnupiravir

V. R. D. Pereira, M. A. M. Bezerra, M. R. B. P. Gomez, G. M. Martins, A. D. da Silva, K. T. de Oliveira, R. O. M. A. de Souza and G. W. Amarante, RSC Adv., 2022, 12, 30120 DOI: 10.1039/D2RA05064A

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