DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers

Zhou Tong; Xinju Peng; Zhi Tang; Weijun Yang; Wei Deng; Shuang-Feng Yin; Nobuaki Kambe; Renhua Qiu

doi:10.1039/D2RA06231C

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers†

Zhou Tong,^a Xinju Peng,^a Zhi Tang,

^a Weijun Yang,

*^a Wei Deng,*^a Shuang-Feng Yin,

^a Nobuaki Kambe^a and Renhua Qiu

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Chemo/Biosensing and Chemometrics, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China
E-mail: renhuaqiu1@hnu.edu.cn

Abstract

We have developed a transition-metal free protocol for efficient cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones and toluenes/phenols using DTBP as an oxidant. A diverse range of 3-aryl benzofuran-2(3H)-ones, toluenes, and phenols undergo C–H bond cleavage to generate all-carbon quaternary centers in good yields, making this protocol useful for the synthesis of complex molecules. A gram scale experiment was performed in good yield.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D2RA06231C
Article type: Paper
Submitted: 04 Oct 2022
Accepted: 02 Dec 2022
First published: 09 Dec 2022
This article is Open Access

Download Citation

RSC Adv., 2022,12, 35215-35220

Permissions

Request permissions

DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers

Z. Tong, X. Peng, Z. Tang, W. Yang, W. Deng, S. Yin, N. Kambe and R. Qiu, RSC Adv., 2022, 12, 35215 DOI: 10.1039/D2RA06231C

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

RSC Advances

DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers†

Abstract

Supplementary files

Article information

Download Citation

Permissions

DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers

Social activity

Search articles by author

Spotlight

Advertisements