Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles

Eleonora Colombo; Davide Andrea Coppini; Simone Maculan; Pierfausto Seneci; Benedetta Santini; Filippo Testa; Lucia Salvioni; Giovanni Maria Vanacore; Miriam Colombo; Daniele Passarella

doi:10.1039/D2RA06306A

Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles†

Eleonora Colombo,

^a Davide Andrea Coppini,

^a Simone Maculan,^a Pierfausto Seneci,

^a Benedetta Santini,^a Filippo Testa,

^b Lucia Salvioni,^b Giovanni Maria Vanacore,^c Miriam Colombo

^b and Daniele Passarella

*^a

Author affiliations

* Corresponding authors

^a Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy
E-mail: daniele.passarella@unimi.it

^b Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy

^c Dipartimento di Scienza dei Materiali, Università degli Studi di Milano Bicocca, Via Roberto Cozzi 55, 20125 Milano, Italy

Abstract

Hetero-nanoparticles self-assembled from a conjugate bearing folic acid as the targeting agent, and another bearing paclitaxel as the active agent are reported. Hetero-nanoparticles containing varying percentages of folic acid conjugates are characterised, and their biological activity is determined.

RSC Advances

Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles

Social activity

Search articles by author

Spotlight

Advertisements