Selective and stable tetraphosphite for Rh-catalyzed linear hydroaminomethylation of aliphatic and aromatic terminal olefins

Abstract

A selective and stable tetraphosphite ligand was reported for rhodium-catalyzed linear hydroaminomethylation of aliphatic and aromatic terminal olefins with an unprecedentedly high TOF (up to 12 060 h⁻¹), high chemoselectivities (up to 99.9% amine) and high regioselectivities (up to 99.9% linear isomer). Such a catalytic method demonstrates a practical and straightforward route to the billion-dollar drug cinacalcet at a remarkably high catalyst efficiency and atom economy (S/C = 10 000).