Issue 2, 2022

De novo generation of a bright blue fluorophore from 2-oxoglutarate in biological samples

Abstract

We discovered the generation of a new bright blue fluorophore from a particular type of amine and 2-oxoglutarate (2-OG) under mild conditions without any chemical additives. Two β-aminoethylamine molecules and three 2-OG molecules form an unprecedented 2-pyridone structure with a fused γ-lactam ring (DTPP) via complex reactions including double decarboxylation and quintuple dehydration. The DTPP fluorophore shows a high quantum yield (80%) and photostability. The great potential of the present DTPP generation in the quantitative analysis of 2-OG in biosamples is demonstrated.

Graphical abstract: De novo generation of a bright blue fluorophore from 2-oxoglutarate in biological samples

Supplementary files

Article information

Article type
Edge Article
Submitted
21 Oct 2021
Accepted
24 Nov 2021
First published
07 Dec 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2022,13, 365-372

De novo generation of a bright blue fluorophore from 2-oxoglutarate in biological samples

Y. Kim, S. Kang, B. H. Lee, Y. Song, S. Kang, H. Y. Park and Y. Lee, Chem. Sci., 2022, 13, 365 DOI: 10.1039/D1SC05808H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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