Issue 23, 2022

Cold-catalytic antitumor immunity with pyroelectric black phosphorus nanosheets

Abstract

Catalytic nanomedicine with the innate features of catalysts brings incomparable properties to biomedicine over traditional drugs. The temperature-dependent activity of catalysts provides catalytic nanomedicines with a facile strategy to control their therapeutic performance. Tuning catalytic nanomedicine by cold treatment (4–37 °C) is safe and desired for practical applications, but there is a lack of cold-catalytic platforms. Herein, with black phosphorus (BP) as a model pyroelectric nanocatalyst, we explored the potential of cold-catalysts for antitumor therapy. BP nanosheets with pyro-catalytic activity catalyze the generation of oxidative stress to activate antitumor immunity under cold treatment. Due to the cold-catalytic immunomodulation, immune memory was successfully achieved to prevent tumor metastasis and recurrence. Considering the safety and conductive depth (>10 mm) of cold in the body, pyroelectric nanocatalysts open up exciting opportunities for the development of cold-catalytic nanomedicine.

Graphical abstract: Cold-catalytic antitumor immunity with pyroelectric black phosphorus nanosheets

Supplementary files

Article information

Article type
Edge Article
Submitted
01 Apr 2022
Accepted
16 May 2022
First published
17 May 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2022,13, 6842-6851

Cold-catalytic antitumor immunity with pyroelectric black phosphorus nanosheets

X. Wu, M. Wen, Y. Zou, X. Gao, C. Wei, R. Liu, J. Li, L. Wang, X. Li, Y. Liu and W. Chen, Chem. Sci., 2022, 13, 6842 DOI: 10.1039/D2SC01894B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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