Volume 1, 2022

Turn-on fluorescent sensors for Cu-rich amyloid β peptide aggregates

Abstract

Protein misfolding and metal dishomeostasis are two key pathological factors of Alzheimer's disease. Previous studies have shown that Cu-mediated amyloid β (Aβ) peptide aggregation leads to the formation of neurotoxic Aβ oligomers. Herein, we report a series of picolinic acid-based Cu-activatable sensors, which can be used for the fluorescence imaging of Cu-rich Aβ aggregates.

Graphical abstract: Turn-on fluorescent sensors for Cu-rich amyloid β peptide aggregates

Supplementary files

Article information

Article type
Communication
Submitted
17 Feb 2022
Accepted
09 May 2022
First published
09 May 2022
This article is Open Access
Creative Commons BY-NC license

Sens. Diagn., 2022,1, 709-713

Turn-on fluorescent sensors for Cu-rich amyloid β peptide aggregates

Y. Huang, L. Sun and L. M. Mirica, Sens. Diagn., 2022, 1, 709 DOI: 10.1039/D2SD00028H

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