Issue 27, 2022

Tumor-triggered targeting ammonium bicarbonate liposomes for tumor multimodal therapy

Abstract

Tumor-triggered targeting ammonium bicarbonate (TTABC) liposomes were proposed to improve the uptake of ammonium bicarbonate (ABC) liposomes in tumor cells and retain their long circulation in vivo in our previous study. However, it must be solved how to precisely release the loaded drugs of the TTABC liposomes into tumor cells. In addition, synergistic multimodal therapy could result in better tumor treatment outcomes than monomodal chemotherapy. In the research, we prepared indocyanine green (ICG) and doxorubicin (DOX) encapsulated TTABC liposomes (ICG&DOX@TTABC) to achieve near-infrared (NIR) light-controlled chemo/photothermal/photodynamic multimodal therapy guided by fluorescence and photothermal imaging. In vitro and vivo studies show that ICG&DOX@TTABC can specifically accumulate in tumor tissues, effectively transform NIR light into local thermo-therapy, and have excellent anti-tumor ability without obvious side effects. ICG&DOX@TTABC could be promising for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic tumor treatment.

Graphical abstract: Tumor-triggered targeting ammonium bicarbonate liposomes for tumor multimodal therapy

Supplementary files

Article information

Article type
Paper
Submitted
25 Feb 2022
Accepted
18 May 2022
First published
19 May 2022

J. Mater. Chem. B, 2022,10, 5154-5164

Tumor-triggered targeting ammonium bicarbonate liposomes for tumor multimodal therapy

Q. Chen, M. Shen, X. Ren, S. Zhu, J. Shang, W. Liu, Z. Zhang, Z. Dong, H. Gu, X. Zhang, Q. Yuan and T. Zou, J. Mater. Chem. B, 2022, 10, 5154 DOI: 10.1039/D2TB00409G

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