Nanoscale patterning of polymers on DNA origami

Abstract

The combination of DNA–origami and synthetic polymers paves the way to a new class of structurally precise biohybrid nanomaterials for diverse applications. Herein, we introduce the grafting to method with high conversions (70–90%) under ambient conditions to generate DNA–polymer conjugates, which can hybridized precisely to DNA–origami architectures. We generated homo and block copolymers from three different polymer families (acrylates, methacrylates and acrylamides), coupled them to single stranded DNA (ssDNA) and pattern different DNA–origami architectures to demonstrate the formation of precise surface nanopatterns.