Issue 33, 2022
From the journal:

Journal of Materials Chemistry B

Mechanically active small intestinal submucosa hydrogel for accelerating chronic wound healing†

Xiao-Ya Chen, ORCID logo ‡a   Yi Wang,‡bc   Shi-Qing Ma,d   Yi-Qian Huang, ORCID logo e   Wei Jing,ef   Peng-Fei Wei,*ef   Xue-Qiao Yu*e  and  Bo Zhao*e  

* Corresponding authors

a College of Bioengineering and Technology, Tianjin Medical University, Tianjin, China

b Department of Physical Education, Renmin University of China, Beijing, China

c School of Life Science and Technology, Harbin Institute of Technology, Harbin, China

d Department of Stomotology, The Second Hospital of Tianjin Medical University, Tianjin, China

e Beijing Biosis Healing Biological Technology Co., Ltd, Beijing, China
E-mail: weipengfei@biosishealing.com, yuxueqiao@biosishealing.com, zhaobo@biosishealing.com

f Foshan (Southern China) Institute for New Materials, Foshan, China

Abstract

The treatment of chronic wounds is still a challenge worldwide. Here, inspired by mechanically induced embryonic wound healing, we design a mechanically active small intestinal submucosa based hydrogel (SIS-PNIPAm). The mechanical activity, biocompatibility, and bioactivity (angiogenesis and immunoregulation) of the SIS-PNIPAm hydrogel enable the fast healing of diabetic rat full-thickness wounds.

Graphical abstract: Mechanically active small intestinal submucosa hydrogel for accelerating chronic wound healing

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Article information

DOI
https://doi.org/10.1039/D2TB01355J
Article type
Communication
Submitted
28 Jun 2022
Accepted
26 Jul 2022
First published
27 Jul 2022

J. Mater. Chem. B, 2022,10, 6279-6286

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Mechanically active small intestinal submucosa hydrogel for accelerating chronic wound healing

X. Chen, Y. Wang, S. Ma, Y. Huang, W. Jing, P. Wei, X. Yu and B. Zhao, J. Mater. Chem. B, 2022, 10, 6279 DOI: 10.1039/D2TB01355J

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