Multi-scene visual hydrazine hydrate detection based on a dibenzothiazole derivative

Abstract

Hydrazine (N₂H₄) produced by industries is distributed into different environments, and seriously threatens ecology and human security. Hence, it is important to develop probes that detect N₂H₄ in various environments. In this study, a novel N₂H₄ fluorescent probe was prepared based on a dibenzothiazole derivative (DBTD). The obtained DBTD probe demonstrated a strong ratio of colorimetric detection of N₂H₄, a rapid response, and good selectivity and sensitivity (detection limit 0.438 μM). Based on its good performance, the DBTD probe was successfully applied for the determination of trace N₂H₄ in water, cells, and zebrafish. In addition, the results of the fluorescence colocalization experiment demonstrated the lysosomal-targetable ability of DBTD.