Issue 8, 2023

A multi-enzyme-like activity exhibiting mussel-inspired nanozyme hydrogel for bacteria-infected wound healing

Abstract

Bacterial infection, tissue hypoxia, and inflammatory and oxidative stress are several key problems in wound healing of chronic infections. Herein, a multi-enzyme-like activity exhibiting multifunctional hydrogel made up of mussel-inspired carbon dot reduced-Ag (CDs/AgNPs) and Cu/Fe-nitrogen-doped carbon (Cu,Fe-NC) was designed. Due to the loss of glutathione (GSH) and oxidase (OXD)-like activity of the nanozyme (decomposes O2 to generate a superoxide anion radical (O2˙) and hydroxyl radical production (˙OH)), the multifunctional hydrogel exhibited excellent antibacterial performance. More importantly, during the bacterial elimination within the inflammatory phase of wound healing, the hydrogel could act as a catalase (CAT)-like agent to supply adequate O2 by catalyzing intracellular H2O2 for hypoxia abatement. The catechol groups on the CDs/AgNPs endowed them with the dynamic redox equilibrium properties of phenol-quinones, thus providing the hydrogel with mussel-like adhesion properties. The multifunctional hydrogel was shown to excellently promote bacterial infection wound healing and maximize the efficiency of nanozymes.

Graphical abstract: A multi-enzyme-like activity exhibiting mussel-inspired nanozyme hydrogel for bacteria-infected wound healing

Supplementary files

Article information

Article type
Paper
Submitted
06 Dec 2022
Accepted
24 Jan 2023
First published
02 Feb 2023

Biomater. Sci., 2023,11, 2711-2725

A multi-enzyme-like activity exhibiting mussel-inspired nanozyme hydrogel for bacteria-infected wound healing

J. Zhu, Q. Han, Q. Li, F. Wang, M. Dong, N. Liu, X. Li, D. Chen, D. Yang, Y. Song and Y. Yang, Biomater. Sci., 2023, 11, 2711 DOI: 10.1039/D2BM02004A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements