Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury

Chaoyan Han; Xin Zhao; Xiaokui Huo; Zhenlong Yu; Chao Wang; Lei Feng; Jingnan Cui; Xiangge Tian; Xiaochi Ma

doi:10.1039/D2CC04237A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury†

Chaoyan Han,‡^ab Xin Zhao,‡^c Xiaokui Huo,

^a Zhenlong Yu,^b Chao Wang,

^b Lei Feng,

*^ade Jingnan Cui,

^c Xiangge Tian

*^a and Xiaochi Ma

*^af

Author affiliations

* Corresponding authors

^a Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China

^b College of Pharmacy, Dalian Medical University, Dalian 116044, China

^c State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

^d School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China

^e Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China

^f Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China

Abstract

An endoplasmic reticulum targeting NIR fluorescent probe (ERBM) was developed for real-time monitoring of carboxylesterase 1 (CES1) and exhibited excellent ER location in living cell imaging. In addition, ERBM was applied to illustrate the regulation characteristics of CES1 under ER stress and acute liver injury models at the cell and animal level.

This article is part of the themed collection: Chemosensors and Molecular Logic

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D2CC04237A
Article type: Communication
Submitted: 29 Jul 2022
Accepted: 12 Dec 2022
First published: 13 Dec 2022

Download Citation

Chem. Commun., 2023,59, 1145-1148

Permissions

Request permissions

Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury

C. Han, X. Zhao, X. Huo, Z. Yu, C. Wang, L. Feng, J. Cui, X. Tian and X. Ma, Chem. Commun., 2023, 59, 1145 DOI: 10.1039/D2CC04237A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury

Social activity

Search articles by author

Spotlight

Advertisements