Issue 24, 2023

Self-assembled anion channel formation by bis(1,3-propanediol)-linked meta-dipropynylbenzene-based small molecules

Abstract

Two self-assembled barrel-rosette ion channels have been developed using bis(1,3-propanediol)-linked m-dipropynylbenzene-based molecules. The system with an additional amide arm acted as a better channel compared to that having an ester arm. The amide-linked channel displayed substantial channel activity and excellent chloride selectivity in the lipid bilayer membranes. Molecular dynamics simulation studies confirmed efficient hydrogen-bonded self-assembly of the amide-linked bis(1,3-propanediol)-based molecules in the lipid bilayer membrane and the detection of chloride recognition in the cavity.

Graphical abstract: Self-assembled anion channel formation by bis(1,3-propanediol)-linked meta-dipropynylbenzene-based small molecules

Supplementary files

Article information

Article type
Communication
Submitted
19 Sep 2022
Accepted
02 Mar 2023
First published
03 Mar 2023

Chem. Commun., 2023,59, 3602-3605

Self-assembled anion channel formation by bis(1,3-propanediol)-linked meta-dipropynylbenzene-based small molecules

R. Sharma, A. Vijay, S. Chattopadhayay, A. Mukherjee and P. Talukdar, Chem. Commun., 2023, 59, 3602 DOI: 10.1039/D2CC05155A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements